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Immunosuppression by Inflammation-Stimulated Amplification of Myeloid-Derived Suppressor Cells and Changes in Expression of Immune Checkpoint HHLA2 in Chronic Obstructive Pulmonary Disease.

Lijuan XuFeng-Sen LiMin JiangZheng LiDan XuJing JingJing WangJianbing Ding
Published in: International journal of chronic obstructive pulmonary disease (2023)
In COPD, the bone marrow is stimulated to produce MDSCs, and a large number of MDSCs migrate to airway tissue through peripheral blood and cooperate with HHLA2 to exert an immunosuppressive effect. Whether MDSCs play an immunosuppressive effect during migration needs to be further confirmed.
Keyphrases
  • bone marrow
  • peripheral blood
  • induced apoptosis
  • poor prognosis
  • oxidative stress
  • chronic obstructive pulmonary disease
  • cell cycle arrest
  • lung function
  • cystic fibrosis
  • long non coding rna
  • cell death
  • air pollution