Off-label low dose amitriptyline for insomnia disorder: Patient-reported outcomes.

Mette H BakkerJacqueline G HugtenburgMarcel G SmitsHenriëtte E van der HorstPauline Slottje

Published in: Pharmacoepidemiology and drug safety (2022)

These patient-reported outcomes support the clinical observations that low dose amitriptyline improves sleep maintenance on the short term and that it is generally well tolerated. This further justifies randomized controlled trials in patients with insomnia disorder and sleep maintenance problems to assess the effectiveness and safety of low dose amitriptyline on the short and long term.

Keyphrases

patient reported outcomes
low dose
sleep quality
high dose
randomized controlled trial
physical activity
depressive symptoms
systematic review