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Ovarian Cancer-Specific BRCA-like Copy-Number Aberration Classifiers Detect Mutations Associated with Homologous Recombination Deficiency in the AGO-TR1 Trial.

Philip C SchoutenLisa RichtersDaniel J VisStefan KommossEwald van DijkCorinna ErnstRoelof J C KluinFrederic MarméEsther H LipsSandra SchmidtEsther ScheermanKatharina PrieskeCarolien H M van DeurzenAlexander BurgesPatricia C Ewing-GrahamDimo DietrichAgnes JagerNikolaus de GregorioJan HaukeAndreas du BoisPetra M NederlofLodewyk F A WesselsEric HahnenPhilipp HarterSabine C LinnRita K Schmutzler
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
The newly trained classifiers detected most BRCA-mutated and methylated cancers and all tumors harboring a RAD51C germline mutations. Beyond that, we found an additional substantial proportion of ovarian cancers to be BRCA-like.
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