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γδ TCR ligands: the quest to solve a 500-million-year-old mystery.

Benjamin E WillcoxCarrie R Willcox
Published in: Nature immunology (2019)
γδ T cells have been retained as a lineage over the majority of vertebrate evolution, are able to respond to immune challenges in unique ways, and are of increasing therapeutic interest. However, one central mystery has endured: the identity of the ligands recognized by the γδ T cell antigen receptor. Here we discuss the inherent challenges in answering this question, the new opportunities provided by recent studies, and the criteria by which the field might judge success.
Keyphrases
  • regulatory t cells
  • single cell
  • immune response