A decrease in NR2B expression mediated by DNA hypermethylation induces perioperative neurocognitive disorder in aged mice.
Feifei XuPeilin CongBingqian ZhangHailong DongWenqiang ZuoTingmei WuLi TianLi-Ze XiongPublished in: CNS neuroscience & therapeutics (2023)
Laparotomy cause hippocampus-dependent cognitive decline by hypermethylating the NR2B gene, allowing us to understand the pathogenesis of PND in an epigenetic landscape.
Keyphrases
- cognitive decline
- mild cognitive impairment
- poor prognosis
- dna methylation
- circulating tumor
- genome wide
- gene expression
- cardiac surgery
- high fat diet induced
- patients undergoing
- copy number
- cell free
- single molecule
- bipolar disorder
- single cell
- cognitive impairment
- binding protein
- genome wide identification
- cerebral ischemia
- prefrontal cortex
- long non coding rna
- brain injury
- insulin resistance
- nucleic acid
- circulating tumor cells