SiRNF8 Delivered by DNA Framework Nucleic Acid Effectively Sensitizes Chemotherapy in Colon Cancer.

Zhao GuoHaoyun SongYingxia TianJie XuGuokun ZhangYanan GuoRong ShenDegui Wang

Published in: International journal of nanomedicine (2024)

We have successfully constructed si-DOX-Tet. By inhibiting the expression of RNF8, it enhances the chemotherapy sensitivity of DOX. Therefore, this tetrahedral FNA nanocarrier offers a new approach for the combined treatment of colon cancer.

Keyphrases

nucleic acid
locally advanced
poor prognosis
drug delivery
signaling pathway
circulating tumor
induced apoptosis
cell free
radiation therapy
squamous cell carcinoma
combination therapy
chemotherapy induced
room temperature
dna damage response
ionic liquid
ultrasound guided
dna repair