The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging.
Brian M EganFranziska PohlXavier AndersonShoshana C WilliamsImienreluefe Gregory AdodoPatrick HuntZuoxu WangChen-Hao ChiuAndrea ScharfMatthew C MosleySandeep KumarDaniel L SchneiderHideji FujiwaraFong-Fu HsuKerry KornfeldPublished in: bioRxiv : the preprint server for biology (2023)
genes, including a new DAF-2(A261V) mutant corresponding to a human disease variant, we clarified the mechanism.