Saikosaponin D: A potential therapeutic drug for osteoarthritis.
Junsong JiangYanfeng MengSongfeng HuBenson O A BotchwayYong ZhangXuehong LiuPublished in: Journal of tissue engineering and regenerative medicine (2020)
Osteoarthritis is a degenerative joint disease. Currently, no effective therapeutic exists for osteoarthritis in the clinic setting. Inflammatory response and autophagy are key players in the occurrence and prognosis of osteoarthritis. In recent years, the regulation of inflammation and autophagy signal pathway has been touted as a potential treatment course for osteoarthritis. Saikosaponin D has anti-inflammatory and induces autophagy effects via inhibiting the nuclear transcription factor-κB, mTOR signaling pathways. Here in the report, we analyze and summarize recent evidences pertaining to the relationship between Saikosaponin and osteoarthritis. Published studies were scoured for in research databases, such as PubMed and Scopus with the keywords Saikosaponin and osteoarthritis. Phosphatidylinositol 3-kinase (PI3k)/Akt/mTOR signaling pathway is an important autophagy modulator, and can regulate chondrocytic autophagy, inflammation, and apoptosis. Saikosaponin D alleviates inflammation and regulates autophagy by inhibiting the PI3k/Akt/mTOR signaling pathway. Saikosaponin D could be a potential therapeutic drug for osteoarthritis.
Keyphrases
- signaling pathway
- oxidative stress
- rheumatoid arthritis
- endoplasmic reticulum stress
- cell death
- pi k akt
- knee osteoarthritis
- induced apoptosis
- epithelial mesenchymal transition
- inflammatory response
- transcription factor
- anti inflammatory
- primary care
- randomized controlled trial
- cell cycle arrest
- systematic review
- artificial intelligence
- toll like receptor
- big data
- dna binding
- climate change
- genome wide identification