Short-term outcomes in infants following general anesthesia with low-dose sevoflurane/dexmedetomidine/remifentanil versus standard dose sevoflurane (The TREX trial).
Rita SaynhalathNicola DismaFiona J TavernerBritta Sylvia von Ungern-SternbergDean AndropoulosAnn S NgBenjamin B ShieldsFrancesca IzzoPaul F Lee-ArcherMary Ellen McCannLuigi MontagniniBeate KuppersElena LenaresSuzette SheppardJurgen C de GraaffKatherine J LeeXiaofang WangPeter SzmukAndrew J DavidsonJustin J Skownonull nullPublished in: Anesthesiology (2024)
These early postoperative results suggest that in children less than 2 years of age receiving greater than 2 hours of general anesthesia, the low-dose sevoflurane/dexmedetomidine/remifentanil anesthesia technique and the standard sevoflurane anesthesia technique are broadly clinically similar, with no clear evidence to support choosing one technique over the other.