Minichromosome Maintenance Complex (MCM) Genes Profiling and MCM2 Protein Expression in Cervical Cancer Development.

Gurjeet KaurShandra Devi BalasubramaniamYung Jen LeeVenugopal BalakrishnanChern Ein Oon

Published in: Asian Pacific journal of cancer prevention : APJCP (2019)

The upregulation of MCM genes expressions in cervical carcinogenesis reaffirms MCM as a proliferative marker in DNA replication pathway, whereby proliferation of dysplastic and cancer cells become increasingly dysregulated and uncontrolled. A strong expression of MCM2 protein in HSIL may aid as a concatenated screening tool in detecting pre-cancerous cervical lesions.

Keyphrases

poor prognosis
genome wide
signaling pathway
binding protein
bioinformatics analysis
genome wide identification
long non coding rna
dna methylation
small molecule