Therapeutic thresholds for golimumab serum concentrations during induction and maintenance therapy in ulcerative colitis: results from the GO-LEVEL study.
Mark A SamaanGeorgina CunninghamAravind Gokul TamilarasanLuisa BeltranPolychronis PavlidisShuvra RayJoel MawdsleySimon H AndersonJeremy D SandersonZehra ArkirPeter M IrvingPublished in: Alimentary pharmacology & therapeutics (2020)
GO-LEVEL (NCT03124121) offers further evidence regarding golimumab's exposure-response relationship. Clinicians may consider using therapeutic drug monitoring to optimise golimumab dosing aiming to achieve our suggested therapeutic thresholds of 3.8 μg/mL at week 6 and 2.4 μg/mL during maintenance.