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Therapeutic thresholds for golimumab serum concentrations during induction and maintenance therapy in ulcerative colitis: results from the GO-LEVEL study.

Mark A SamaanGeorgina CunninghamAravind Gokul TamilarasanLuisa BeltranPolychronis PavlidisShuvra RayJoel MawdsleySimon H AndersonJeremy D SandersonZehra ArkirPeter M Irving
Published in: Alimentary pharmacology & therapeutics (2020)
GO-LEVEL (NCT03124121) offers further evidence regarding golimumab's exposure-response relationship. Clinicians may consider using therapeutic drug monitoring to optimise golimumab dosing aiming to achieve our suggested therapeutic thresholds of 3.8 μg/mL at week 6 and 2.4 μg/mL during maintenance.
Keyphrases
  • ulcerative colitis
  • ankylosing spondylitis
  • palliative care
  • clinical trial
  • randomized controlled trial
  • stem cells
  • cell therapy