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Targeted multigene deep sequencing of Bruton tyrosine kinase inhibitor-resistant chronic lymphocytic leukemia with disease progression and Richter transformation.

Rashmi Kanagal-ShamanaPreetesh JainKeyur P PatelMark RoutbortCarlos Bueso-RamosTahani AlhalouliJoseph D KhouryRajyalakshmi LuthraAlessandra FerrajoliMichael KeatingNitin JainJan BurgerZeev EstrovWilliam WierdaHagop M KantarjianL Jeffrey Medeiros
Published in: Cancer (2018)
Longitudinal, targeted, multigene deep sequencing is informative for the clinical monitoring of mutational evolution in patients with CLL who are receiving BTKi.
Keyphrases
  • chronic lymphocytic leukemia
  • single cell
  • cancer therapy
  • cross sectional
  • drug delivery