METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1α pathway and c-Myc expression.
Zhuonan LiuTianshui SunChiyuan PiaoZhe ZhangChui-Ze KongPublished in: Journal of translational medicine (2021)
In general, our finding suggests that high expression of METTL13 is associated with favorable prognosis of ccRCC patients. Meanwhile, METTL13 can inhibit growth and metastasis of ccRCC cells with participation in multiple potential molecular mechanisms. Therefore, we suggest METTL13 can be a new diagnostic and therapeutic target for ccRCC in the future.
Keyphrases
- poor prognosis
- end stage renal disease
- ejection fraction
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- binding protein
- physical activity
- prognostic factors
- peritoneal dialysis
- endothelial cells
- long non coding rna
- cell cycle arrest
- risk assessment
- signaling pathway
- human health
- cell proliferation
- endoplasmic reticulum stress