Melatonin promotes bone marrow mesenchymal stem cell osteogenic differentiation and prevents osteoporosis development through modulating circ_0003865 that sponges miR-3653-3p.

Xudong WangTaiqiu ChenZhihuai DengWenjie GaoTongzhou LiangXianjian QiuBo GaoZizhao WuJincheng QiuYuanxin ZhuYanbo ChenZhancheng LiangHang ZhouCaixia XuAnjing LiangPeiqiang SuYan PengDongsheng Huang

Published in: Stem cell research & therapy (2021)

MEL promotes BMSC osteogenic differentiation and inhibits OP pathogenesis by suppressing the expression of circ_0003865, which regulates GAS1 gene expression via sponging miR-3653-3p.

Keyphrases

bone marrow
mesenchymal stem cells
gene expression
umbilical cord
poor prognosis
dna methylation
postmenopausal women
cell therapy
signaling pathway
bone mineral density
binding protein
body composition
carbon dioxide