The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells.
Yuan YuanCaihua XueQiang WuMengjie WangJiahua LiuLongfei ZhangQianwen XingJingyan LiangHua WuZhangping YangPublished in: Genes & genomics (2021)
Overall, these data suggest that miR-145-5p inhibits the enhancing effect of PCB2 on CD36 expression by binding CD36 and subsequently regulating apoptosis, the immune response and anti-inflammatory pathways. These results provide theoretical and experimental support for the treatment of breast cancer.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- oxidative stress
- immune response
- signaling pathway
- cell cycle arrest
- anti inflammatory
- nk cells
- poor prognosis
- cell death
- breast cancer cells
- binding protein
- machine learning
- big data
- artificial intelligence
- pi k akt
- toll like receptor
- transcription factor
- inflammatory response
- data analysis
- combination therapy