Maternal psychological distress before birth influences gut immunity in mid-infancy.
Liane J KangKhanh N VuPetya T KolevaCatherine J FieldAngela ChowMeghan B AzadAllan B BeckerPiushkumar J MandhaneTheo J MoraesMalcolm R SearsDiana L LefebvreStuart E TurveyPadmaja SubbaraoWendy Y W LouJames A ScottAnita L KozyrskyjPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)
Despite improved mood postpartum and independent of breastfeeding status, mothers experiencing antepartum depressive symptoms delivered offspring who exhibited lower fecal sIgA concentrations especially in later infancy. The implications of lowered sIgA concentrations in infant stool are altered microbe-sIgA interactions, greater risk for C difficile colonization and atopic disease in later years.