New Macrolide-Lincosamide-Streptogramin B Resistance Gene erm(48) on the Novel Plasmid pJW2311 in Staphylococcus xylosus.

Juliette R K WipfMatthew C RileyStephen A KaniaDavid A BemisSabrina AndreisSybille SchwendenerVincent Perreten

Published in: Antimicrobial agents and chemotherapy (2017)

Whole-genome sequencing of Staphylococcus xylosus strain JW2311 from bovine mastitis milk identified the novel 49.3-kb macrolide-lincosamide-streptogramin B (MLSB) resistance plasmid pJW2311. It contained the macrolide resistance gene mph(C), the macrolide-streptogramin B resistance gene msr(A), and the new MLSB resistance gene erm(48) and could be transformed into Staphylococcus aureus by electroporation. Functionality of erm(48) was demonstrated by cloning and expression in S. aureus.

Keyphrases

staphylococcus aureus
genome wide
copy number
escherichia coli
poor prognosis
crispr cas
gene expression
dna methylation
transcription factor
pseudomonas aeruginosa
cystic fibrosis
candida albicans