Login / Signup

Cellular distribution of cannabinoid-related receptors TRPV1, PPAR-gamma, GPR55 and GPR3 in the equine cervical dorsal root ganglia.

Giorgia GaliazzoMargherita De SilvaFiorella GiancolaRiccardo RinnovatiAngelo PeliRoberto Chiocchetti
Published in: Equine veterinary journal (2021)
Cannabinoid-related receptors were distributed in the sensory neurons (TRPV1, PPARγ, GPR55 and GPR3), SGCs (TRPV1, PPARγ and GPR55), macrophages (GPR55) and other interneuronal cells (PPARγ and GPR55) of the equine DRG. Given the key role of DRG cellular elements and cannabinoid receptors in the pathophysiology of pain, the present findings provided an anatomical basis for additional studies aimed at exploring the therapeutic uses of non-psychotropic cannabinoid agonists for the management of pain in horses.
Keyphrases
  • fatty acid
  • neuropathic pain
  • chronic pain
  • spinal cord
  • insulin resistance
  • pain management
  • induced apoptosis
  • spinal cord injury
  • type diabetes
  • skeletal muscle