Efficacy and safety of fezolinetant for vasomotor symptoms in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials.

Syed Muhammad Muneeb Akhtar Abraish Ali Muhammad Sohaib Khan Vareesha Khan Areeba Fareed Syed Zia Saleem Munazza MumtazMuhammad Nadeem AhsanSadia IqbalMuhammad Sohaib Asghar

Published in: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2024)

Our study significantly favors fezolinetant over placebo regarding the primary efficacy outcomes of daily moderate to severe VMS frequency and severity, including PROs, while both the groups are comparable in terms of treatment emergent adverse events. Further studies are needed to confirm these findings.

Keyphrases

postmenopausal women
bone mineral density
systematic review
high intensity
type diabetes
randomized controlled trial
early onset
adipose tissue
skeletal muscle
phase iii
study protocol