Expression and Significance of Inflammatory Factors in Idiopathic Spinal Epidural Lipomatosis (Grade III).
Mingkun YangHang ZhangMinyi LiuXindong JiaTao DuDengpu WuPublished in: Neuro endocrinology letters (2024)
iSEL demonstrated elevated inflammatory cells and imbalance towards proinflammatory cytokines in adipocytes of epidural adipose tissue that may be associated with the pathogenesis of symptomatic iSEL. These data suggest that inflammatory response could be one of the mechanisms of iSEL. However, further multicenter epidemiological investigations and rigorous basic and clinical research are warranted to elucidate the specific etiology of iSEL.
Keyphrases
- adipose tissue
- spinal cord
- inflammatory response
- induced apoptosis
- oxidative stress
- poor prognosis
- insulin resistance
- cell cycle arrest
- high fat diet
- lipopolysaccharide induced
- electronic health record
- spinal cord injury
- lps induced
- endoplasmic reticulum stress
- signaling pathway
- binding protein
- toll like receptor
- cell death
- machine learning
- clinical trial
- metabolic syndrome
- type diabetes
- skeletal muscle
- high fat diet induced