Antimicrobial peptides with cell-penetrating activity as prophylactic and treatment drugs.
Gabriel Del RioMario A Trejo PerezCarlos A BrizuelaPublished in: Bioscience reports (2022)
Health is fundamental for the development of individuals and evolution of species. In that sense, for human societies is relevant to understand how the human body has developed molecular strategies to maintain health. In the present review, we summarize diverse evidence that support the role of peptides in this endeavor. Of particular interest to the present review are antimicrobial peptides (AMP) and cell-penetrating peptides (CPP). Different experimental evidence indicates that AMP/CPP are able to regulate autophagy, which in turn regulates the immune system response. AMP also assists in the establishment of the microbiota, which in turn is critical for different behavioral and health aspects of humans. Thus, AMP and CPP are multifunctional peptides that regulate two aspects of our bodies that are fundamental to our health: autophagy and microbiota. While it is now clear the multifunctional nature of these peptides, we are still in the early stages of the development of computational strategies aimed to assist experimentalists in identifying selective multifunctional AMP/CPP to control nonhealthy conditions. For instance, both AMP and CPP are computationally characterized as amphipatic and cationic, yet none of these features are relevant to differentiate these peptides from non-AMP or non-CPP. The present review aims to highlight current knowledge that may facilitate the development of AMP's design tools for preventing or treating illness.
Keyphrases
- protein kinase
- healthcare
- public health
- mental health
- endothelial cells
- drug delivery
- health information
- single cell
- cell death
- amino acid
- oxidative stress
- cancer therapy
- cell therapy
- signaling pathway
- health promotion
- human health
- bone marrow
- induced pluripotent stem cells
- fluorescent probe
- single molecule
- pluripotent stem cells