Apolipoproteins, lipids, lipid-lowering drugs and risk of amyotrophic lateral sclerosis and frontotemporal dementia: a meta-analysis and Mendelian randomisation study.

Christos V ChalitsiosHarriet LeyJiali Gao Matthew C Kiernan Alexander Guy Thompson

Published in: Journal of neurology (2024)

These data support the influence of LDL-c and total cholesterol on ALS risk and apolipoprotein B on the risk of ALS and FTD. Potential APOB inhibition might decrease the risk of sporadic ALS and FTD. Further work in monogenic forms of ALS and FTD is necessary to determine whether blood lipids influence penetrance and phenotype.

Keyphrases

amyotrophic lateral sclerosis
fatty acid
low density lipoprotein
machine learning
risk assessment
climate change
data analysis