Pyridoxamine protects human granulosa cells against advanced glycation end-products-induced steroidogenesis disturbances.
Maryam MiraniSoghra BahmanpourFatemeh MasjediZahra DerakhshanMahintaj DaraMohammad Hossein Nasr-EsfahaniSeyed Mohammad Bagher TabeiPublished in: Molecular biology reports (2023)
This study indicates that hormonal dysfunctions induced by the AGEs-RAGE axis in luteinized GCs are likely rectified by PM treatment. This effect is likely acquired by reduced expression of RAGE. A better understanding of how AGEs and PM interact in ovarian physiology and pathology may lead to more targeted therapy for treating ovarian dysfunction.
Keyphrases
- particulate matter
- air pollution
- endothelial cells
- induced apoptosis
- high glucose
- polycystic ovary syndrome
- poor prognosis
- polycyclic aromatic hydrocarbons
- heavy metals
- oxidative stress
- cell cycle arrest
- diabetic rats
- type diabetes
- cancer therapy
- combination therapy
- insulin resistance
- long non coding rna
- adipose tissue
- drug delivery
- cell proliferation
- cell death
- pi k akt
- skeletal muscle
- replacement therapy