NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond.
José Martínez-GonzálezLaia CañesJudith AlonsoCarme Ballester-ServeraAntonio Rodriguez-SinovasIrene CorralesCristina RodriguezPublished in: International journal of molecular sciences (2021)
The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases.
Keyphrases
- extracellular matrix
- pulmonary arterial hypertension
- cardiovascular disease
- oxidative stress
- abdominal aortic aneurysm
- transcription factor
- pulmonary artery
- endothelial cells
- pulmonary hypertension
- genome wide identification
- risk factors
- randomized controlled trial
- metabolic syndrome
- coronary artery disease
- systematic review
- binding protein
- cell proliferation
- cell cycle arrest