Skin changes in hairy cell leukemia.
Ewa RobakDorota Jesionek-KupnickaTadeusz RobakPublished in: Annals of hematology (2020)
Skin lesions have been reported in about 10-12% of hairy cell leukemia (HCL) patients. Most are etiologically related to autoimmune or infectious processes, although secondary cutaneous neoplasms and drug-induced lesions are also reported. However, leukemia cutis with the direct infiltration of the skin by leukemic cells is extremely rare in HCL patients. This paper reviews the epidemiology, pathogenesis, clinical symptoms, diagnosis, and approach to treating skin lesions in HCL. A literature review of the MEDLINE database for articles in English concerning hairy cell leukemia, skin lesions, leukemia cutis, adverse events, infectious, cutaneous, drug reactions, neutrophilic dermatoses, secondary neoplasms, and vasculitis was conducted via PubMed. Publications from January 1980 to September 2020 were scrutinized. Additional relevant publications were obtained by reviewing the references from the chosen articles.
Keyphrases
- acute myeloid leukemia
- drug induced
- end stage renal disease
- bone marrow
- soft tissue
- liver injury
- ejection fraction
- single cell
- newly diagnosed
- chronic kidney disease
- cell therapy
- wound healing
- prognostic factors
- adverse drug
- randomized controlled trial
- peritoneal dialysis
- multiple sclerosis
- patient reported outcomes
- depressive symptoms
- case report
- risk factors
- cell death
- cell proliferation
- mesenchymal stem cells
- cell cycle arrest
- oxidative stress