The Effect of Different Antibiotic Regimens on Bacterial Resistance: A Systematic Review.

Despite the great number of studies retrieved by electronic databases only few studies investigated the target of this review. The reason for this evidence is that it is not ethical to investigate and compare different antibiotic regimens, shorter or longer than the appropriate one. This evidence is applicable both to prophylactic administrations and to those aimed at treating infections. Besides this, the WHO affirms that, in the absence of infective complications, the prescription of antibiotic after every type of surgical intervention cannot be admitted and that studies dealing with antibiotic regimens that do not comply with drug's pharmacodynamics characteristics cannot be ethically admitted. PROSPERO acknowledgement of receipt [149149].