Is There Clinical Improvement Associated With Intradiscal Therapies? A Comparison Across Randomized Controlled Studies.
Derek G JuLinda E KanimHyun W BaePublished in: Global spine journal (2020)
A single-center analysis of 4 randomized controlled studies demonstrated no difference in outcomes between therapeutic intradiscal agents (growth factor, fibrin sealant, or stem cells) and control saline groups. In all groups, patient reported pain and disability scores decreased significantly. Future studies are needed to evaluate the therapeutic benefit of any intradiscal injections.
Keyphrases
- growth factor
- stem cells
- patient reported
- double blind
- case control
- open label
- placebo controlled
- phase iii
- multiple sclerosis
- chronic pain
- phase ii
- clinical trial
- pain management
- type diabetes
- randomized controlled trial
- neuropathic pain
- platelet rich plasma
- metabolic syndrome
- skeletal muscle
- current status
- spinal cord
- insulin resistance