High doses of dexamethasone induce endoplasmic reticulum stress-mediated apoptosis by promoting calcium ion influx-dependent CHOP expression in osteoblasts.

Published in: Molecular biology reports (2021)

High doses of Dex induce CHOP expression by promoting calcium ion influx-dependent induction of ATF6, phosphorylated PERK and phosphorylated IRE1, which induce endoplasmic reticulum stress-mediated apoptosis in osteoblasts. 2-APB protects the osteoblasts from the effects of Dex, preventing endoplasmic reticulum stress-mediated apoptosis.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
poor prognosis
diffuse large b cell lymphoma
low dose
high dose
long non coding rna
oxidative stress
signaling pathway