A Novel Humanized Immune Stroma PDX Cancer Model for Therapeutic Studies.

Dongli YangIan BeddowsHuijuan TangSandra CascioStacy C McGonigalShoumei BaiBenjamin K JohnsonJohn J PowersRajesh AcharyaRiyue BaoTullia C BrunoThing R SoongJose R Conejo-GarciaHui ShenMoses Turkle BilityRonald J Buckanovich

Published in: bioRxiv : the preprint server for biology (2023)

We developed a tumor model with human stromal, vascular, and immune cells. This model mirrors patient response to chemotherapy, targeted therapy, and immunotherapy, and can be used to study therapy resistance.

Keyphrases

endothelial cells
bone marrow
squamous cell carcinoma
stem cells
case report
papillary thyroid
squamous cell
pluripotent stem cells