Insulin-Resistant Pathways Are Associated With Disease Activity in Rheumatoid Arthritis and Are Subject to Disease Modification Through Metabolic Reprogramming: A Potential Novel Therapeutic Approach.
Lorna GallagherSian CreganMonika BinieckaClare CunninghamDouglas J VealeDavid J KaneUrsula FearonRonan H MullanPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Insulin resistance is significantly associated with BMI and synovitis in RA, suggesting distinct interplay between glucose availability and inflammation in RA. Furthermore, the effect of metformin on proinflammatory mechanisms suggests a role for AMPK-modifying compounds in the treatment of RA.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- ankylosing spondylitis
- rheumatoid arthritis patients
- insulin resistance
- type diabetes
- juvenile idiopathic arthritis
- body mass index
- interstitial lung disease
- oxidative stress
- skeletal muscle
- adipose tissue
- metabolic syndrome
- glycemic control
- blood glucose
- high fat diet
- polycystic ovary syndrome
- physical activity
- climate change
- systemic sclerosis
- high fat diet induced
- smoking cessation