Fusobacterium nucleatum impairs DNA mismatch repair and stability in patients with squamous cell carcinoma of the head and neck.
Chi-Yao HsuehHui-Ching LauQiang HuangHongli GongJi SunPengyu CaoChunyan HuMing ZhangLei TaoLiang ZhouPublished in: Cancer (2022)
This study clearly indicates that Fusobacterium induced head and neck squamous cell carcinoma (HNSCC) aggressiveness to affect poor prognosis in HNSCC patients by epigenetic alteration of DNA mismatch repair (MMR) and microsatellite instability. Moreover, the research has shown that Fusobacterium nucleatum ( F. nucleatum ) impacts HNSCC epigenetic changes in tissues with deficient MMR to promote DNA damage and cell proliferation by suppressing MMRrelated gene expression via the TLR4/MYD88/miR-205-5p signaling pathway.
Keyphrases
- gene expression
- poor prognosis
- dna methylation
- dna damage
- squamous cell carcinoma
- cell proliferation
- long non coding rna
- signaling pathway
- end stage renal disease
- circulating tumor
- toll like receptor
- newly diagnosed
- ejection fraction
- single molecule
- pi k akt
- oxidative stress
- cell free
- chronic kidney disease
- high glucose
- peritoneal dialysis
- prognostic factors
- diabetic rats
- cell cycle
- dna repair
- patient reported outcomes
- nuclear factor
- induced apoptosis
- rectal cancer