The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 431.

Alexandre Maximiliano Trevisan Bruno Cogliati Adriana Ribeiro Homem Thiago Pinheiro Arrais Aloia Nelson de Aquino Neto Jairo Marques Moreira Leonardo da Cruz Reno Alexandre Moulin Naumann Flávio Henrique Ferreira Galvão Wellington Andraus Luiz Augusto Carneiro D Albuquerque

Published in: Acta cirurgica brasileira (2019)

This research demonstrated that the deficiency of Cx43 worses the prognosis for liver injury. The topic is a promising target for therapeutics advancements in liver diseases and procedures.

Keyphrases

liver injury
drug induced
mouse model
poor prognosis
acute myocardial infarction
cerebral ischemia
small molecule
binding protein
heart failure
acute ischemic stroke
replacement therapy
percutaneous coronary intervention