Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.
Simon Kebede MeridAlexei NovoloacaGemma C SharpLeanne K KüpersAlvin T KhoRitu RoyLu GaoIsabella Annesi-MaesanoPooja JainMichelle PlusquinManolis KogevinasCatherine AllardFlorianne O VehmeijerNabila KazmiLucas A SalasFaisal I RezwanHongmei ZhangSylvain SebertDarina CzamaraSheryl L Rifas-ShimanPhillip E MeltonDebbie A LawlorGöran PershagenCarrie V BretonKaren HuenNour BaizLuigi GagliardiTim S NawrotEva CorpeleijnPatrice PerronLiesbeth DuijtsEllen Aagaard NohrMariona BustamanteSusan L EwartWilfried KarmausShanshan ZhaoChristian M PageZdenko HercegMarjo-Riitta JarvelinJari LahtiAndrea A BaccarelliDenise AndersonPriyadarshini KachrooCaroline L ReltonAnna BergströmBrenda EskenaziMunawar Hussain SoomroPaolo VineisHarold SniederLuigi BouchardVincent W JaddoeThorkild I A SørensenMartine VrijheidS Hasan ArshadJohn W HollowaySiri E HåbergPer MagnusTerence DwyerElisabeth B BinderDawn L DeMeoJudith M VonkJohn NewnhamKelan G TantisiraInger KullJoseph L WiemelsBarbara HeudeJordi SunyerWenche NystadMonica C Munthe-KaasKatri RäikkönenEmily OkenRae-Chi HuangScott T WeissJosep Maria AntóJean BousquetAshish KumarCilla SöderhällCatarina AlmqvistAndres CardenasOlena GruzievaCheng-Jian XuSarah E ReeseJuha KerePetter BrodinOlivia SolomonMatthias WielscherNina HollandAkram GhantousMarie-France HivertJanine F FelixGerard H KoppelmanStephanie J LondonErik MelénPublished in: Genome medicine (2020)
We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.