Long-term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy.
Javier VilladiegoSonia Romo-MaderoRoberto García-SwinburnNela Suárez-LunaAlfonso Bermejo-NavasMiriam EchevarríaJuan José Toledo-AralPublished in: Xenotransplantation (2018)
This new immunosuppressive protocol provides a new murine model to assay the long-term effects of cerebral xenografts and offer a pharmacological alternative to the commonly used genetic immunodeficient mice, allowing the use of genetically modified mice as hosts. In addition, it will permit the experimental analysis of the effects produced by human CB xenografts in the chronic PD murine model, with the final aim of using CB allografts as an option of cell therapy in PD patients.
Keyphrases
- cell therapy
- stem cells
- mesenchymal stem cells
- end stage renal disease
- high fat diet induced
- newly diagnosed
- chronic kidney disease
- endothelial cells
- ejection fraction
- randomized controlled trial
- prognostic factors
- peritoneal dialysis
- high throughput
- gene expression
- metabolic syndrome
- subarachnoid hemorrhage
- type diabetes
- dna methylation
- bone marrow
- copy number
- adipose tissue
- skeletal muscle