Hypoxia-Sonic Hedgehog Axis as a Driver of Primitive Hematopoiesis Development and Evolution in Cavefish.

Corine M van der WeeleKatrina C HospesKatherine E RoweWilliam R Jeffery

Published in: bioRxiv : the preprint server for biology (2024)

Hypoxia increases hematopoiesis and erythrocytes in surface fishShh upregulation increases hematopoiesis and erythrocytes in surface fishShh inhibition decreases hematopoiesis and erythrocytes in cavefishHypoxia upregulates Shh along the embryonic midline in surface fish.

Keyphrases

hematopoietic stem cell
endothelial cells
cell proliferation
poor prognosis
signaling pathway