Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice.
Zhuo ChengLiping WangMeijie QuHuaibin LiangWanlu LiYongfang LiLidong DengZhijun ZhangYongting WangPublished in: Journal of neuroinflammation (2018)
The results showed that mesenchymal stem cell therapy attenuated blood-brain barrier disruption in mice after ischemia. Mesenchymal stem cells attenuated the upward trend of MMP-9 and potentially via downregulating ICAM-1 in endothelial cells. Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway may influence MMP-9 expression of neutrophils and resident cells, and ICAM-1 acted as a key factor in the paracrine actions of mesenchymal stem cell.
Keyphrases
- blood brain barrier
- mesenchymal stem cells
- cell therapy
- protein kinase
- cerebral ischemia
- umbilical cord
- bone marrow
- endothelial cells
- high fat diet induced
- stem cells
- induced apoptosis
- poor prognosis
- cell cycle arrest
- subarachnoid hemorrhage
- wild type
- cell migration
- patient safety
- metabolic syndrome
- adipose tissue
- cell proliferation
- signaling pathway