Comparison of A(H3N2) Neutralizing Antibody Responses Elicited by 2018-2019 Season Quadrivalent Influenza Vaccines Derived from Eggs, Cells, and Recombinant Hemagglutinin.
Wei WangEsmeralda Alvarado-FacundoRussell VassellLimone CollinsRhonda E ColomboAnuradha GanesanCasey GeaneyDavid HrncirTahaniyat LalaniAna Elizabeth MarkelzRyan C MavesBruce McClenathanKatrin MendeStephanie A RichardChristina SchofieldSrihari SeshadriChristina SpoonerGregory C UtzTyler E WarkentienMin LevineChristian L ColesTimothy H BurgessMaryna EichelbergerCarol D WeissPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Egg- and cell-derived 2018-2019 season influenza vaccines elicited similar neutralization titers and response rates, indicating that the cell-derived vaccine did not improve immunogenicity against the A(H3N2) viruses. The higher responses after rHA vaccination may be due to its higher HA content. All vaccines boosted titers to HA with egg-adaptive substitutions, suggesting boosting from past antigens or better exposure of HA epitopes. Studies comparing immunogenicity and effectiveness of different influenza vaccines across many seasons are needed.