Impact of PNPLA3 p.I148M and Hepatic Steatosis on Long-Term Outcomes for Hepatocellular Carcinoma and HBsAg Seroclearance in Chronic Hepatitis B.
Rei-Chi HsuehWan-Jung WuChih-Lin LinChun-Jen LiuYi-Wen HuangJui-Ting HuChih-Feng WuFeng-Yu SungWen-Jie LiuMing-Whei YuPublished in: Journal of hepatocellular carcinoma (2022)
Hepatic steatosis and PNPLA3-148M variant appeared to have distinct impacts on the development of HBV-related progressive liver disease and HCC. PNPLA3 p.I148M, but not a diagnosis of hepatic steatosis, can help to identify HBV carriers with high-risk fatty liver disease in the progression to HCC.