Effects of sleep fragmentation and estradiol decline on cortisol in a human experimental model of menopause.
Aviva Y CohnLeilah K GrantMargo D NathanAleta WileyMathena AbramsonJessica A HarderSybil CrawfordElizabeth B KlermanFrank A J L ScheerUrsula B KaiserShadab A RahmanHadine JoffePublished in: The Journal of clinical endocrinology and metabolism (2023)
Both estradiol suppression and modifiable menopause-related sleep fragmentation independently perturb HPA axis activity. Sleep fragmentation, commonly seen in menopausal women, may disrupt the HPA axis, which in turn may lead to adverse health effects as women age.