The Effects of Adjuvant Fermented Wheat Germ Extract on Cancer Cell Lines: A Systematic Review.
Khrystyna ZhurakivskaGiuseppe TroianoVito Carlo Alberto CaponioMario DioguardiClaudia ArenaLorenzo Lo MuzioPublished in: Nutrients (2018)
Fermented wheat germ extract (FWGE; trade name AVEMAR) is a natural compound derived from industrial fermentation of wheat germ. Its potential anticancer properties has emerged from recent studies. The aim of this systematic review is to summarize the data available in the scientific literature concerning the in vitro activity of FWGE on malignant cells. A systematic review of English articles in electronic databases has been performed. The primary outcomes of the review regarded types of cancer cell lines subjected to the investigation and the main results concerning cell viability, proliferation, and apoptosis observed within the studies. Sixteen articles were included in the final qualitative analysis. Various types of cancer cells treated with FWGE have been analyzed, showing mainly cytotoxic effects, alteration of the cell cycle, antiproliferative effects, and induction of apoptosis. FWGE can be a promising drug component in cancer treatment; however, further in vitro and in vivo studies are necessary to prove its effectiveness and safety in humans.
Keyphrases
- systematic review
- cell cycle
- cell cycle arrest
- oxidative stress
- papillary thyroid
- induced apoptosis
- endoplasmic reticulum stress
- cell death
- case control
- squamous cell
- cell proliferation
- meta analyses
- big data
- signaling pathway
- pi k akt
- randomized controlled trial
- type diabetes
- electronic health record
- risk assessment
- lymph node metastasis
- adipose tissue
- skeletal muscle
- young adults
- deep learning
- insulin resistance
- childhood cancer