Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients With Localized Prostate Cancer: Results From the FLAME Randomized Phase III Trial.
Linda G W KerkmeijerVeerle H GroenFloris J PosKarin HaustermansEvelyn M MonninkhofRobert Jan SmeenkMartina Kunze-BuschJohannes C J de BoerJochem van der Voort van ZijpMarco van VulpenCédric DraulansLaura van den BerghSofie IsebaertUulke A van der HeidePublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
The addition of a focal boost to the intraprostatic lesion improved bDFS for patients with localized intermediate- and high-risk prostate cancer without impacting toxicity and quality of life. The Focal Lesion Ablative Microboost in Prostate Cancer study shows that a high focal boost strategy to improve tumor control while respecting organ at risk dose constraints is effective and safe.