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Risk analysis of systemic levels of estrogen and adipokines as well as estrogen receptors from PBMCs in childbearing and perimenopausal women with obesity.

Huijuan FanShujiao ChenBizhen GaoShanshan DingQiang ZhaoCandong LiTetsuya Asakawa
Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2019)
Our data fundamentally contradicts the utility of circulating ERα and ERα/ERβ evaluations in obesity studies. Because estrogen exerts pleiotropic effects on multiple tissues in the body through differential regulation of ERs, although the expression of ERβ coincides with the results of a previous study on adipose tissue, the expression levels of ERs in blood cannot be used as a diagnostic of informative tool for obesity in women.
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