Risk analysis of systemic levels of estrogen and adipokines as well as estrogen receptors from PBMCs in childbearing and perimenopausal women with obesity.
Huijuan FanShujiao ChenBizhen GaoShanshan DingQiang ZhaoCandong LiTetsuya AsakawaPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2019)
Our data fundamentally contradicts the utility of circulating ERα and ERα/ERβ evaluations in obesity studies. Because estrogen exerts pleiotropic effects on multiple tissues in the body through differential regulation of ERs, although the expression of ERβ coincides with the results of a previous study on adipose tissue, the expression levels of ERs in blood cannot be used as a diagnostic of informative tool for obesity in women.
Keyphrases
- estrogen receptor
- insulin resistance
- metabolic syndrome
- adipose tissue
- weight loss
- poor prognosis
- high fat diet induced
- endoplasmic reticulum
- type diabetes
- weight gain
- polycystic ovary syndrome
- breast cancer cells
- high fat diet
- gene expression
- postmenopausal women
- skeletal muscle
- pregnant women
- body mass index
- big data
- machine learning
- artificial intelligence
- deep learning
- case control
- data analysis
- breast cancer risk