m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC.

Dan JinJiwei GuoYan WuLijuan YangXiaohong WangJing DuJuanjuan DaiWeiwei ChenKaikai GongShuang MiaoXuelin LiHongliang Sun

Published in: Molecular cancer (2020)

The presented findings suggest m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC. Moreover, effective inhibition of m6A modification of ALKBH5 might constitute a potential treatment strategy for lung cancer.

Keyphrases

poor prognosis
long non coding rna
small cell lung cancer
cell proliferation
signaling pathway
long noncoding rna
risk assessment
climate change
epidermal growth factor receptor