Danhong Injection Alleviates Cardiac Fibrosis via Preventing the Hypermethylation of Rasal1 and Rassf1 in TAC Mice.

Sinai LiPing LiWeihong LiuJuju ShangShenglei QiuXiang LiWei LiuHaoyue ShiMingxue Zhou Hongxu Liu

Published in: Oxidative medicine and cellular longevity (2020)

Aberrant DNA methylation of Rasal1 and Rassf1 genes was involved in the CF development. DHI treatment alleviated CF, prevented the hypermethylation of Rasal1 and Rassf1, and downregulated DNMT3B expression in CF hearts.

Keyphrases

cystic fibrosis
dna methylation
genome wide
poor prognosis
gene expression
left ventricular
mouse model
heart failure
ultrasound guided
type diabetes
transcription factor
metabolic syndrome
combination therapy
skeletal muscle
wild type