Lentiviral Mediated Expression of Soluble Neuropilin 1 Inhibits Semaphorin 3A-mediated Collapse Activity in Vitro .

Keivan Nedaei Mahdi Hesaraki Saeideh Mazloumzadeh Mehdi Totonchi Ali Reza Biglari

Published in: Basic and clinical neuroscience (2021)

Our results indicated that msNRP1 was successfully produced in HEK293T cells. The secreted msNRP1 effectively prevented Sema 3A collapse activity. Therefore, msNRP1 can increase remyelination in MS lesions, although more studies using animal models are required.

Keyphrases

poor prognosis
mass spectrometry
multiple sclerosis
ms ms
binding protein