IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway.

Shyng-Shiou F YuanYun-Ming WangLeong-Perng ChanAmos C HungHieu D H NguyenYuk-Kwan ChenStephen Chu-Sung HuSteven LoYen-Yun Wang

Published in: Journal of translational medicine (2023)

The current study suggests that IL-1RA promoted OSCC malignancy through mitochondrial metabolism-mediated EGFR/JNK activation and SOX2 expression. Inhibition of this mitochondrial metabolic pathway may present a potential therapeutic strategy in OSCC.

Keyphrases

oxidative stress
small cell lung cancer
epidermal growth factor receptor
rheumatoid arthritis
stem cells
signaling pathway
transcription factor
tyrosine kinase
cell death
induced apoptosis
poor prognosis
ankylosing spondylitis
systemic lupus erythematosus
long non coding rna
idiopathic pulmonary fibrosis