The Promise of Polygenic Risk Prediction in Smoking Cessation: Evidence From Two Treatment Trials.
Michael BrayYoonhoo ChangTimothy B BakerDouglas JorenbyRobert M CarneyLouis FoxGiang PhamFaith R StonekingNina SmockChristopher Ian AmosLaura BierutLi-Shiun ChenPublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2022)
There is a potential for polygenic risk scores to inform future clinical medicine, and a great need for evidence on whether these scores predict clinically meaningful outcomes. Our meta-analysis provides early evidence for potential utility of using polygenic risk scores to predict smoking cessation amongst smokers undergoing quit attempts, informing further work to optimize the use of polygenic risk scores in clinical care.