Relationship between updated MELD and prognosis in alcohol-associated hepatitis: Opportunities for more efficient trial design.
Mustafa Al-KaraghouliMeritxell Ventura-CotsYu Jun WongJoan GenescaFrancisco BosquesRobert S BrownPhilippe MathurinAlexandre LouvetDebbie ShawcrossVictor VargasElizabeth C VernaBernd SchnablJoan CaballeriaVijay J ShahPatrick S KamathMichael R LuceyGuadalupe Garcia-TsaoRamon BatallerJuan G AbraldesPublished in: Hepatology communications (2024)
We show that updated MELDs during the trajectory of AH predict subsequent mortality or the need for transplant. MELD28 inclusion in an ordinal outcome (together with death or transplant) could increase the efficiency of randomized controlled trials.