Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes.

Eva Korpos Nadir KadriSophie LoismannClais R Findeisen Frank Arfuso George W Burke Sarah J Richardson Noel G Morgan Marika Bogdani Alberto Pugliese Lydia M Sorokin

Published in: Diabetologia (2021)

We demonstrate a novel feature of pancreas pathology in type 1 diabetes. TLOs represent a potential site of autoreactive effector T cell generation in islet autoimmunity and our data from mouse and human tissues suggest that they disappear once the destructive process has run its course. Thus, TLOs may be important for type 1 diabetes progression.

Keyphrases

type diabetes
endothelial cells
glycemic control
cardiovascular disease
insulin resistance
induced pluripotent stem cells
pluripotent stem cells
gene expression
deep learning
electronic health record
immune response
metabolic syndrome
big data
climate change
artificial intelligence
bioinformatics analysis