Safety and Tolerability of Oral Cannabinoids in People Living with HIV on Long-Term ART: A Randomized, Open-Label, Interventional Pilot Clinical Trial (CTNPT 028).
Ralph-Sydney Mboumba BouassaJudy NeedhamDana NohynekJoel SingerTerry LeeFlorian BobeufSuzanne SamaraniLina Del BalsoNatalie PaisibleClaude VertzagiasGiada SebastianiShari MargoleseEnrico MandarinoMarina KleinBertrand LebouchéJoseph CoxMarie-Josée BrouilletteJean-Pierre RoutyJason SzaboRéjean ThomasEmmanuel HuchetAntonio ViganoMohammad-Ali JenabianCecilia T CostiniukPublished in: Biomedicines (2022)
In PLWH, cannabinoids seem generally safe and well-tolerated, though larger studies are needed. Screening for occult liver pathology should be performed and hepatic enzymes monitored, especially with high CBD doses.